Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation.

@article{Shiota2010Foxo3aSO,
  title={Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation.},
  author={Masaki Shiota and Yoohyun Song and Akira Yokomizo and Keijiro Kiyoshima and Yasuhiro Tada and Hiroshi Uchino and Takeshi Uchiumi and Junichi Inokuchi and Yoshinao Oda and Kentaro Kuroiwa and Katsunori Tatsugami and Seiji Prof Naito},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 23},
  pages={
          5654-63
        }
}
PURPOSE Invasion and metastasis are key steps in the progression of urothelial cancer (UC) into a critical disease. Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various genes. We aimed to elucidate the role of Foxo3a in UC invasion. EXPERIMENTAL DESIGN Foxo3a mRNA and protein expressions in UC samples were investigated by gene expression assays and immunohistochemistry, respectively. Foxo3a expression was compared with clinicopathologic… CONTINUE READING

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