Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142.

@article{Kawahara2015Foxo3aIO,
  title={Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142.},
  author={Teppei Kawahara and Noritaka Kagaya and Yuichi Masuda and Takayuki Doi and Miho Izumikawa and Kumiko Ohta and Atsushi Hirao and Kazuo Shin-Ya},
  journal={Organic letters},
  year={2015},
  volume={17 21},
  pages={5476-9}
}
JBIR-141 (1) and JBIR-142 (2) were discovered as potent Foxo3a inhibitors that consist of three quite unique substructures, a 1-((dimethylamino)ethyl)-5-methyl-4,5-dihydrooxazole-4-carboxylic acid that is originated from Ala-Thr amino acid residues, a 3-acetoxy-4-amino-7-(hydroxy(nitroso)amino)-2,2-dimethylheptanoic acid, and an α-acyl tetramic acid fused… CONTINUE READING