Foxo3 is required for the regulation of oxidative stress in erythropoiesis.

@article{Marinkovic2007Foxo3IR,
  title={Foxo3 is required for the regulation of oxidative stress in erythropoiesis.},
  author={Dragan Marinkovic and Xin Zhang and Safak Yalcin and Julia P Luciano and Carlo Brugnara and Tara L Huber and Saghi Ghaffari},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 8},
  pages={2133-44}
}
Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in erythroid cells have thus far been poorly characterized. We observed that animals deficient in the forkhead box O3 (Foxo3) transcription factor died rapidly when exposed to erythroid oxidative stress-induced conditions, while wild-type mice showed no decreased viability. In view of this striking finding, we… CONTINUE READING