Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.

@article{John2008Foxo3IA,
  title={Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.},
  author={George Babu John and Teresa D. Gallardo and Lane J Shirley and Diego H. Castrillon},
  journal={Developmental biology},
  year={2008},
  volume={321 1},
  pages={197-204}
}
In mammals, oocytes are packaged into compact structures-primordial follicles-which remain inert for prolonged intervals until individual follicles resume growth via a process known as primordial follicle activation. Here we show that the phosphoinositide 3-kinase (PI3K) signalling pathway controls primordial follicle activation through the forkhead transcription factor Foxo3. Within oocytes, Foxo3 is regulated by nucleocytoplasmic shuttling. Foxo3 is imported into the nucleus during primordial… CONTINUE READING
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