Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.

@article{Yasui2007Foxo1RE,
  title={Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.},
  author={Atsutaka Yasui and Hitoshi Nishizawa and Yosuke Okuno and Kentaro Morita and Hironori Kobayashi and Kenichiro Kawai and Morihiro Matsuda and Ken Kishida and Shinji Kihara and Yasutomi Kamei and Yoshihiro Ogawa and Tohru Funahashi and Iichiro Shimomura},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={364 2},
  pages={358-65}
}
Musclin is a novel skeletal muscle-derived secretory factor, whose mRNA level is markedly regulated by nutritional status. In the present study, we investigated the mechanism of musclin mRNA regulation by insulin. In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the… CONTINUE READING

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