Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

@article{Amin2008Foxo1DR,
  title={Foxo1 directly regulates the transcription of recombination-activating genes during B cell development},
  author={Rupesh H. Amin and Mark S Schlissel},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={613-622}
}
Regulated expression of the recombinase RAG-1 and RAG-2 proteins is necessary for generating the vast repertoire of antigen receptors essential for adaptive immunity. Here, a retroviral cDNA library screen showed that the stress-regulated protein GADD45a activated transcription of the genes encoding RAG-1 and RAG-2 in transformed pro–B cells by a pathway requiring the transcription factor Foxo1. Foxo1 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development… CONTINUE READING
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