Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

  title={Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells},
  author={Weiming Ouyang and Omar Beckett and Qian Ma and Ji-hye Paik and Ronald A. Depinho and Ming O Li},
  journal={Nature Immunology},
CD4+ regulatory T cells (Treg cells) characterized by expression of the transcription factor Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice with T cell–specific deletion of both the Foxo1 and Foxo3 transcription factors (collectively called 'Foxo proteins' here) developed a fatal multifocal inflammatory disorder due in part to Treg cell defects. Foxo proteins functioned in a Treg cell–intrinsic manner to regulate thymic and transforming growth factor… CONTINUE READING
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Ablation in mice of the mtOrC components raptor , rictor , or mLSt 8 reveals that mtOrC 2 is required for signaling to AktFOXO and PKC α , but not S 6 K 1

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