Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

@article{Sandri2004FoxoTF,
  title={Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy},
  author={Marco Sandri and Cl{\'a}udia Langhi Sandri and Alex Gilbert and Carsten Skurk and Elisa Calabria and Anne Picard and Kenneth Walsh and Stefano Schiaffino and Stewart H. Lecker and Alfred L Goldberg},
  journal={Cell},
  year={2004},
  volume={117},
  pages={399-412}
}
Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. In atrophying muscles, the ubiquitin ligase, atrogin-1 (MAFbx), is dramatically induced, and this response is necessary for rapid atrophy. Here, we show that in cultured myotubes undergoing atrophy, the activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 1,221 CITATIONS, ESTIMATED 54% COVERAGE

Therapeutic Ultrasound in Dentistry

  • Springer International Publishing
  • 2018
VIEW 22 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

  • Journal of cachexia, sarcopenia and muscle
  • 2012
VIEW 23 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2019

CITATION STATISTICS

  • 187 Highly Influenced Citations

  • Averaged 64 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

The many forks in FOXO's road.

  • Science's STKE : signal transduction knowledge environment
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2004

Similar Papers

Loading similar papers…