Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1.

@article{Wang2007Foxl2UA,
  title={Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1.},
  author={Deshou Wang and Tohru Kobayashi and Lin-yan Zhou and Bindhu Paul-Prasanth and Shigeho Ijiri and Fumie Sakai and K Okubo and Ken-ichirou Morohashi and Yoshitaka Nagahama},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 3},
  pages={712-25}
}
Increasing evidence suggests the crucial role of estrogen in ovarian differentiation of nonmammalian vertebrates including fish. The present study has investigated the plausible role of Foxl2 in ovarian differentiation through transcriptional regulation of aromatase gene, using monosex fry of tilapia. Foxl2 expression is sexually dimorphic, like Cyp19a1, colocalizing with Cyp19a1 and Ad4BP/SF-1 in the stromal cells and interstitial cells in gonads of normal XX and sex-reversed XY fish, before… CONTINUE READING
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