Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.

Abstract

The bones of the vertebrate face develop from transient embryonic branchial arches that are populated by cranial neural crest cells. We have characterized a mouse mutant for the Forkhead family transcription factor Foxi3, which is expressed in branchial ectoderm and endoderm. Foxi3 mutant mice are not viable and display severe branchial arch-derived facial… (More)
DOI: 10.1016/j.ydbio.2014.03.004

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