Foxg1 suppresses early cortical cell fate.

@article{Hanashima2004Foxg1SE,
  title={Foxg1 suppresses early cortical cell fate.},
  author={Carina Hanashima and Suzanne C Li and Lijian Shen and Eseng Lai and Gordon Fishell},
  journal={Science},
  year={2004},
  volume={303 5654},
  pages={
          56-9
        }
}
During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later born neuron fate is unknown. We demonstrate here that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex. By conditionally… CONTINUE READING

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