Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11.

@article{Kawauchi2009Foxg1PO,
  title={Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11.},
  author={Shimako Kawauchi and Joon Kyung 김준경 Kim and Rosaysela Santos and Hsiao-Huei Wu and Arthur D. Lander and Anne L. Calof},
  journal={Development},
  year={2009},
  volume={136 9},
  pages={
          1453-64
        }
}
  • Shimako Kawauchi, Joon Kyung 김준경 Kim, +3 authors Anne L. Calof
  • Published in Development 2009
  • Biology, Medicine
  • Foxg1, a winged-helix transcription factor, promotes the development of anterior neural structures; in mice lacking Foxg1, development of the cerebral hemispheres and olfactory epithelium (OE) is severely reduced. It has been suggested that Foxg1 acts by positively regulating the expression of growth factors, such as Fgf8, which support neurogenesis. However, Foxg1 also binds Smad transcriptional complexes, allowing it to negatively regulate the effects of TGFbeta family ligands. Here, we… CONTINUE READING

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