Foxa2 regulates multiple pathways of insulin secretion.

  title={Foxa2 regulates multiple pathways of insulin secretion.},
  author={Kristen A Lantz and Marko Z. Vatamaniuk and John Brestelli and Joshua R Friedman and Franz M. Matschinsky and Klaus H. Kaestner},
  journal={The Journal of clinical investigation},
  volume={114 4},
The regulation of insulin secretion by pancreatic beta cells is perturbed in several diseases, including adult-onset (type 2) diabetes and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). The first mouse model for PHHI has a conditional deletion of the gene encoding the winged-helix transcription factor Foxa2 (Forkhead box a2, formerly Hepatocyte nuclear factor 3beta) in pancreatic beta cells. Using isolated islets, we found that Foxa2 deficiency resulted in excessive insulin release… CONTINUE READING
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