Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.

@article{Chen2010Foxa2PT,
  title={Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.},
  author={Gang Chen and Huajing Wan and Fengming Luo and Liqian Zhang and Yan Xu and Ian P Lewkowich and Marsha Wills-Karp and Jeffrey A. Whitsett},
  journal={Journal of immunology},
  year={2010},
  volume={184 11},
  pages={6133-41}
}
After birth, the respiratory tract adapts to recurrent exposures to pathogens, allergens, and toxicants by inducing the complex innate and acquired immune systems required for pulmonary homeostasis. In this study, we show that Foxa2, expressed selectively in the respiratory epithelium, plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation. Deletion of the Foxa2 gene, encoding a winged helix/forkhead box transcription factor that is selectively… CONTINUE READING

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