Foxa2 is essential for mouse endometrial gland development and fertility.

  title={Foxa2 is essential for mouse endometrial gland development and fertility.},
  author={Jae-Wook Jeong and Inseok Kwak and Kevin Y-S Lee and Tae Hoon Kim and Michael J. Large and Colin Lawson Stewart and Klaus H. Kaestner and John P. Lydon and Francesco J. Demayo},
  journal={Biology of reproduction},
  volume={83 3},
During embryonic development, Foxa2 is required for the formation of the node and notochord, and ablation of this gene results in defects in gastrulation, neural tube patterning, and gut morphogenesis. Foxa2 has been shown to be expressed specifically in the glandular epithelium of the murine uterus. To study the uterine function of Foxa2, this gene was conditionally ablated in the mouse uterus by crossing mice with floxed Foxa2 alleles, Foxa2(loxP/loxP), with the Pgr(cre) mouse model. Pgr(cre… CONTINUE READING
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