Foxa2 integrates the transcriptional response of the hepatocyte to fasting.

  title={Foxa2 integrates the transcriptional response of the hepatocyte to fasting.},
  author={Liping Zhang and Nir E Rubins and Rexford S. Ahima and Linda E. Greenbaum and Klaus H. Kaestner},
  journal={Cell metabolism},
  volume={2 2},
Survival during prolonged food deprivation depends on the activation of hepatic gluconeogenesis. Inappropriate regulation of this process is a hallmark of diabetes and other metabolic diseases. Activation of the genes encoding gluconeogenic enzymes is mediated by hormone-responsive transcription factors such as the cyclic AMP response element binding protein (CREB) and the glucocorticoid receptor (GR). Here we show using cell-type-specific gene ablation that the winged helix transcription… CONTINUE READING

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