Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

Abstract

The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development. Importantly, Foxa2+ cells contribute to previously identified progenitor populations in a defined pattern and ratio. Lastly, we describe an analogous Foxa2+ population during differentiation of embryonic stem cells. Together, these findings provide insight into the developmental origin of ventricular and atrial cells, and may lead to the establishment of new strategies for generating chamber-specific cell types from pluripotent stem cells.

DOI: 10.1038/ncomms14428

Cite this paper

@inproceedings{Bardot2017Foxa2IA, title={Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential}, author={Evan S. Bardot and Damelys Calderon and Francis J. Santoriello and Songyan Han and Kakit Cheung and Bharati Jadhav and Ingo Burtscher and Stanley Artap and Rajan Jain and Jonathan Epstein and Heiko Lickert and Val{\'e}rie Gouon-Evans and Andrew Sharp and Nicole C. Dubois}, booktitle={Nature communications}, year={2017} }