Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs

@inproceedings{Maier2013Foxa1AF,
  title={Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs},
  author={Jennifer A. Maier and Yinting Lo and Brian D Harfe},
  booktitle={PloS one},
  year={2013}
}
The intervertebral disc (IVD) is composed of 3 main structures, the collagenous annulus fibrosus (AF), which surrounds the gel-like nucleus pulposus (NP), and hyaline cartilage endplates, which are attached to the vertebral bodies. An IVD is located between each vertebral body. Degeneration of the IVD is thought to be a major cause of back pain, a potentially chronic condition for which there exist few effective treatments. The NP forms from the embryonic notochord. Foxa1 and Foxa2… CONTINUE READING
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