FoxP3+ regulatory CD4 T cells control the generation of functional CD8 memory

Abstract

During the primary immune response, CD8 memory emerges from an environment of strong immune activation. The FoxP3(+) regulatory CD4 T-cell subset (Treg) is known as a key suppressive component of the immune system. Here we report that Tregs are required for the generation of functional CD8 memory. In the absence of Tregs during priming, the resulting memory… (More)
DOI: 10.1038/ncomms1992

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