FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing.

@article{Adam2016FoxP2DR,
  title={FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing.},
  author={Iris Adam and Ezequiel Mendoza and Ursula Kobalz and Sandra Wohlgemuth and Constance Scharff},
  journal={Molecular and cellular neurosciences},
  year={2016},
  volume={74},
  pages={96-105}
}
Mutations of the transcription factor FOXP2 cause a severe speech and language disorder. In songbirds, FoxP2 is expressed in the medium spiny neurons (MSNs) of the avian basal ganglia song nucleus, Area X, which is crucial for song learning and adult song performance. Experimental downregulation of FoxP2 in Area X affects spine formation, prevents neuronal plasticity induced by social context and impairs song learning. Direct target genes of FoxP2 relevant for song learning and song production… CONTINUE READING