FoxO3 controls autophagy in skeletal muscle in vivo.

@article{Mammucari2007FoxO3CA,
  title={FoxO3 controls autophagy in skeletal muscle in vivo.},
  author={Cristina Mammucari and Giulia Milan and Vanina Romanello and Eva Masiero and R{\"u}diger Rudolf and Paola del Piccolo and Steven J Burden and Raffaella Di Lisi and Claudia Sandri and Jinghui Zhao and Alfred L Goldberg and Stefano Schiaffino and Marco Sandri},
  journal={Cell metabolism},
  year={2007},
  volume={6 6},
  pages={458-71}
}
Autophagy allows cell survival during starvation through the bulk degradation of proteins and organelles by lysosomal enzymes. However, the mechanisms responsible for the induction and regulation of the autophagy program are poorly understood. Here we show that the FoxO3 transcription factor, which plays a critical role in muscle atrophy, is necessary and sufficient for the induction of autophagy in skeletal muscle in vivo. Akt/PKB activation blocks FoxO3 activation and autophagy, and this… CONTINUE READING
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