FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

@inproceedings{AlTamari2018FoxO3AI,
  title={FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis},
  author={Hamza M Al-Tamari and Swati Dabral and Anja Schmall and Pouya Sarvari and Clemens Ruppert and Jihye Paik and Ronald A DePinho and Friedrich Grimminger and Oliver Eickelberg and Andreas Guenther and Werner Seeger and Rajkumar Savai and Soni S Pullamsetti},
  booktitle={EMBO molecular medicine},
  year={2018}
}
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, with fibroblast-to-myofibroblast transdifferentiation and hyperproliferation playing a major role. Investigating ex vivo-cultured (myo)fibroblasts from human IPF lungs as well as fibroblasts isolated from bleomycin-challenged mice, Forkhead box O3 (FoxO3) transcription factor was found to be less expressed, hyperphosphorylated, and nuclear-excluded relative to non-diseased… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Regulation of PDGF and its receptors in fibrotic diseases.

  • Cytokine & growth factor reviews
  • 2004
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Akt promotes

A Brunet, A Bonni, +7 authors ME Greenberg
  • cell
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL