FoxO1 regulates apoptosis induced by asbestos in the MT-2 human T-cell line.

@article{Matsuzaki2016FoxO1RA,
  title={FoxO1 regulates apoptosis induced by asbestos in the MT-2 human T-cell line.},
  author={Hidenori Matsuzaki and Suni Lee and Megumi Maeda and Naoko Kumagai-Takei and Yasumitsu Nishimura and Takemi Otsuki},
  journal={Journal of immunotoxicology},
  year={2016},
  volume={13 5},
  pages={620-7}
}
Asbestos is known to cause malignant mesothelioma and lung cancer. Recent studies implicate tumor immunity in the development of various tumors, including malignant mesothelioma. In order to establish an in vitro T-cell model to clarify the effects of long-term exposure of asbestos on tumor immunity, in this study, human T-cell line MT-2 cells were cultured with asbestos for longer than 8 months and the resultant cells (MT-2Rst) were assessed for the expression of forkhead transcription factor… CONTINUE READING
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