FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

  title={FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake},
  author={Hongxia Ren and Ian J. Orozco and Ya Su and Shigetomo Suyama and Roger Guti{\'e}rrez-Ju{\'a}rez and Tam{\'a}s L. Horv{\'a}th and Sharon L Wardlaw and Leona Plum and Ottavio Arancio and Domenico Accili},
Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so. FoxO1 is a shared mediator of both pathways, and its inhibition is required to induce satiety. Accordingly, FoxO1 ablation in AgRP neurons of mice results in reduced food intake, leanness, improved… CONTINUE READING
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