FoxO1, the transcriptional chief of staff of energy metabolism.

  title={FoxO1, the transcriptional chief of staff of energy metabolism.},
  author={Stavroula Kousteni},
  volume={50 2},
FoxO1, one of the four FoxO isoforms of Forkhead transcription factors, is highly expressed in insulin-responsive tissues, including pancreas, liver, skeletal muscle and adipose tissue, as well as in the skeleton. In all these tissues FoxO1 orchestrates the transcriptional cascades regulating glucose metabolism. Indeed, FoxO1 is a major target of insulin which inhibits its transcriptional activity via nuclear exclusion. In the pancreas, FoxO1 regulates β-cell formation and function by a… CONTINUE READING
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