FoxO transcription factors promote autophagy in cardiomyocytes.

@article{Sengupta2009FoxOTF,
  title={FoxO transcription factors promote autophagy in cardiomyocytes.},
  author={Arunima Sengupta and Jeffery D Molkentin and Katherine E. Yutzey},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 41},
  pages={28319-31}
}
In the heart, autophagy is required for normal cardiac function and also has been implicated in cardiovascular disease. FoxO transcription factors promote autophagy in skeletal muscle and have additional roles in regulation of cell size, proliferation, and metabolism. Here we investigate the role of FoxO transcription factors in regulating autophagy and cell size in cardiomyocytes. In cultured rat neonatal cardiomyocytes, glucose deprivation leads to decreased cell size and induction of… CONTINUE READING
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