FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression.

@article{Petrovic2008FoxM1RG,
  title={FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression.},
  author={Vladimir Petrovic and Robert H. Costa and Lester F. Lau and Pradip Raychaudhuri and Angela L. Tyner},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 1},
  pages={
          453-60
        }
}
The Forkhead box M1 (FoxM1) transcription factor is essential for cell cycle progression and mitosis. FoxM1 regulates expression of Skp2 and Cks1, subunits of the SCF ubiquitin ligase complex, which ubiquitinates p27(Kip1) and targets it for degradation. Kinase-interacting stathmin (KIS) is a growth factor-dependent nuclear kinase that regulates cell cycle progression by phosphorylating p27(Kip1) to promote its nuclear export. Here we present an additional mechanism of FoxM1-mediated regulation… CONTINUE READING
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