FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.

  title={FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.},
  author={Pamela A. Hoodless and Melanie Pye and Claire Chazaud and Etienne Labb{\'e} and Liliana Attisano and Janet Rossant and Jeffrey L. Wrana},
  journal={Genes & development},
  volume={15 10},
The node and the anterior visceral endoderm (AVE) are important organizing centers that pattern the mouse embryo by establishing the anterior-posterior (A-P), dorsal-ventral (D-V), and left-right (L-R) axes. Activin/nodal signaling through the Smad2 pathway has been implicated in AVE formation and in morphogenesis of the primitive streak, the anterior end of which gives rise to the node. The forkhead DNA-binding protein, FoxH1 (or Fast), functions as a Smad DNA-binding partner to regulate… CONTINUE READING

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