FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus.

@article{Yaklichkin2007FoxD3AG,
  title={FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus.},
  author={Sergey Yu Yaklichkin and Aaron B. Steiner and Qun Lu and Daniel Solomon Kessler},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 4},
  pages={
          2548-57
        }
}
FoxD3 is a forkhead-related transcriptional regulator that is essential for multiple developmental processes in the vertebrate embryo, including neural crest development and maintenance of mammalian stem cell lineages. Recent results demonstrate a requirement for FoxD3 in Xenopus mesodermal development. In the gastrula, FoxD3 functions as a transcriptional repressor in the Spemann organizer to maintain the expression of Nodal-related members of the transforming growth factor-beta superfamily… CONTINUE READING
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