FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.

@article{Seiliez2006FoxA3AG,
  title={FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.},
  author={Iban Seiliez and Bernard V Thisse and Christine I Thisse},
  journal={Developmental biology},
  year={2006},
  volume={290 1},
  pages={152-63}
}
Formation of the nervous system initially requires the acquisition of neural identity, which is achieved through the inhibition of epidermalizing factors. A regional patterning then takes place within the neural plate through the activity of caudalizing factors. These two processes are tightly regulated early in development by the dorsal organizer. Here, we show that, in zebrafish embryos, two transcription factors, FoxA3 and Goosecoid, coexpressed at the dorsal blastula margin, are required… CONTINUE READING

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