FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.

@article{Ionescu2012FoxAFM,
  title={FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.},
  author={Andreia Ionescu and Elena A Kozhemyakina and Claudia Nicolae and Klaus H. Kaestner and Bjorn Reino Olsen and Andrew B. Lassar},
  journal={Developmental cell},
  year={2012},
  volume={22 5},
  pages={
          927-39
        }
}
During endochondral ossification, small, immature chondrocytes enlarge to form hypertrophic chondrocytes, which express collagen X. In this work, we demonstrate that FoxA factors are induced during chondrogenesis, bind to conserved binding sites in the collagen X enhancer, and can promote the expression of a collagen X-luciferase reporter in both chondrocytes and fibroblasts. In addition, we demonstrate by both gain- and loss-of-function analyses that FoxA factors play a crucial role in driving… CONTINUE READING

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