Fourteen‐day Toxicity Study of 1,3,5‐Trinitrobenzene in Fischer 344 Rats

  title={Fourteen‐day Toxicity Study of 1,3,5‐Trinitrobenzene in Fischer 344 Rats},
  author={T. Reddy and G. Olson and B. Wiechman and G. Reddy and M. Robinson and J. Torsella and F. Daniel},
  journal={Journal of Applied Toxicology},
Toxic effects of 1,3,5‐trinitrobenzene (TNB) in male and female rats were evaluated by feeding powdered certified laboratory chow diet supplemented with varied concentrations of TNB (0, 50, 200, 400, 800 and 1200 mg kg−1 diet) for 14 days. Food intake by female rats in 400, 800 and 1200 mg TNB diet groups was reduced and resulted in a significant decrease in absolute body weights (BW). Food and water consumption by male rats in high‐dose groups (800 and 1200 mg TNB kg−1 diet) was also reduced… Expand
Subchronic Toxicity of 1,3,5-Trinitrobenzene in Fischer 344 Rats
The subchronic toxicity of 1,3,5-trinitrobenzene (TNB) in male and female Fischer 344 rats was evaluated by feeding a powdered certified laboratory diet containing 0, 66.7, 400 and 800 mg TNBl kgExpand
Oral Toxicity of 3-Nitro-1,2,4-triazol-5-one in Rats
3-Nitro-1,2,4-triazol-5-one (NTO), an insensitive explosive, was evaluated to assess potential environmental and human health effects and testicular effects were the most sensitive adverse effect and were used to derive a benchmark dose (BMD) of 70 mg/kg-d with a 10% effect level (BMDL10) of 40 mg/ kg-d. Expand
Wildlife Toxicity Assessment for 1,3,5-Trinitrobenzene (TNB)
Abstract 1,3,5-Trinitrobenzene (TNB) is a nitroaromatic compound that is used as an explosive and is released to the environment during the manufacturing process and as a degradation or by-product ofExpand
The para isomer of dinitrobenzene disrupts redox homeostasis in liver and kidney of male wistar rats
Findings show that sub-chronic oral and sub-dermal administration of p-DNB may produce hepato-nephrotoxicity through oxidative stress. Expand
Oral Toxicity of 2,4-Dinitroanisole in Rats
Stereotypical behavior in males, gait irregularities, and cerebellar lesions indicated that DNAN is neurotoxic, likely owing to its conversion to 2,4-dinitrophenol, an inhibitor of energy homeostasis. Expand
Toxicity of Tetryl (N-Methyl-N,2,4,6–Tetranitroaniline) in F344 Rats
The toxicity of tetryl (N-methyl-N,2,4,6–tetranitroaniline) in male and female F344 rats was evaluated after adminstration in the diet for 14 or 90 days. The 14–day study diet concentrations usedExpand
Assessment of environmental hazards of 1,3,5-trinitrobenzene.
Based on the newly determined NOAEL and LOAEL values, a new RfD for TNB is developed, based on the chronic toxic effects on hematology and histopathological changes in testes and kidney, for subchronic, chronic, reproductive, and developmental toxicity. Expand
Toxicological Guidelines for Monocyclic Nitro-, Amino- and Aminonitroaromatics, Nitramines, and Nitrate Esters in Drinking Water
  • K. Wollin, H. Dieter
  • Environmental Science, Medicine
  • Archives of environmental contamination and toxicology
  • 2005
For toxicological evaluation and derivation of guideline values for the NCs of interest, the tolerable daily intake approach was used for chemicals exhibiting a threshold for toxic effects, and suitable estimates of excess lifetime cancer risk have been applied. Expand
In Vitro Inhibition of Mammalian Glutathione Transferases by Selected Nitrobenzenes
Five structurally related nitrobenzenes (1,2-dinitrobenzene, 1,3-dinitrobenzene, 1,4-dinitrobenzene, 1,3,5-trinitrobenzene, and picric acid) and Meisenheimer complexExpand
Aromatic Nitro and Amino Compounds
Logically, aromatic nitro and amino compounds should be discussed together because their toxic responses are often similar due to a common metabolic intermediate. Synthetically, amines are generallyExpand