Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products

@article{Floresta2019FourfoldFS,
  title={Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products},
  author={Giuseppe Floresta and E. Amata and Davide Gentile and G. Romeo and A. Marrazzo and V. Pittal{\`a} and L. Salerno and A. Rescifina},
  journal={Marine Drugs},
  year={2019},
  volume={17}
}
  • Giuseppe Floresta, E. Amata, +5 authors A. Rescifina
  • Published 2019
  • Chemistry, Medicine
  • Marine Drugs
  • Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human cancer, and in these cases, poor clinical outcomes are normally reported. Indeed, the inhibition of HO-1 is being considered as an anticancer approach. Imidazole scaffold is normally present in most of the classical HO-1 inhibitors and seems indispensable to the inhibitory activity due to its strong interaction with the Fe(II) of the heme group. In this paper, we searched for new potentially HO-1… CONTINUE READING
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