• Corpus ID: 28235522

Four years follow-up of bone mineral density change in premenopausal women with systemic lupus erythematosus.

@article{Uaratanawong2004FourYF,
  title={Four years follow-up of bone mineral density change in premenopausal women with systemic lupus erythematosus.},
  author={Somchai Uaratanawong and Utis Deesomchok and Narin Hiransuttikul and Somsri Uaratanawong},
  journal={Journal of the Medical Association of Thailand = Chotmaihet thangphaet},
  year={2004},
  volume={87 11},
  pages={
          1374-9
        }
}
OBJECTIVE To measure the change in bone mineral density (BMD) in premenopausal women with systemic lupus erythematosus (SLE) during 4 years of follow-up, and to identify the role of glucocorticoid and disease related variables. METHOD Premenopausal women with SLE were clinically evaluated and underwent BMD measurement of the lumbar spine, femoral neck and trochanter by dual energy x-ray absorptiometry. RESULTS 106 SLE patients were evaluated with a mean age of 31.7 +/- 7.5 years, duration… 
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References

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TLDR
Loss of lumbar spine and femoral neck BMD in this premenopausal female SLE population was minimal for the group as a whole; however, a daily dose of prednisolone of > or =7.5 mg was associated with loss of l Dumbar spine BMD, and in corticosteroid exposed patients, regular exercise was protective of femoral head BMD loss.
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TLDR
BMD in premenopausal patients with SLE was less than that in a control group and less than the reference range of values defining the presence of osteoporosis in 12.1%, and there was no relationship between BMD and either cumulative or baseline dose of corticosteroid therapy.
Bone mineral density in premenopausal women with systemic lupus erythematosus.
TLDR
BMD measurements were significantly lower in premenopausal SLE patients who had had corticosteroid treatment than those who had not, and prevalence of osteoporosis, based on lumbar spine BMD, was lower than that reported in Caucasians.
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TLDR
SLE causes significant trabecular bone loss, which is not due to corticosteroid therapy, and BMD at Ward's triangle and at the femoral neck was not significantly reduced in the SLE patients.
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TLDR
After 18 months there was no significant decrease in bone mineral density, despite glucocorticoid treatment (table), in either the lumbar spine or the femoral neck, in premenopausal SLE patients.
ORIGINAL CLINICAL PAPERS: LONGITUDINAL BONE MINERAL DENSITY CHANGES IN EARLY RHEUMATOID ARTHRITIS
TLDR
It is suggested that significant bone loss occurs within the first few months of disease in patients with RA, with significant differences found between RA patients and controls overall.
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TLDR
Premenopausal women with SLE taking prolonged steroid therapy had lower BMD but showed no significant bone loss over the 2 year study period, and the beneficial effect of calcitriol treatment in these premenopausal women was small.
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TLDR
Comparison of BMDs between patients ever and never treated with glucocorticoids indicated that patients who had ever received glucoc Corticoids had a significantly lower lumbar spine BMD compared to those who never did, suggesting that the disease per se might induce some bone loss.
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