Four weeks of oral isotretinoin treatment causes few signs of general toxicity in male and female Sprague-Dawley rats.

Abstract

Despite widespread use of isotretinoin for its anti-acne effects and its current evaluation in clinical trials as a cancer treatment, little is known about its general toxicity in adult nonpregnant animals, particularly after oral administration which mimics the human route. Here, adult male and female Sprague-Dawley rats were gavaged daily with 0 (soy oil… (More)

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@article{Ferguson2005FourWO, title={Four weeks of oral isotretinoin treatment causes few signs of general toxicity in male and female Sprague-Dawley rats.}, author={Sherry Ann Ferguson and Francisco J. Cisneros and Bobby J Gough and Syed F. Ali}, journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}, year={2005}, volume={43 8}, pages={1289-96} }