Four-week intravenous repeated dose toxicity study of L-cysteine in male rats.

@article{Sawamoto2003FourweekIR,
  title={Four-week intravenous repeated dose toxicity study of L-cysteine in male rats.},
  author={Osamu Sawamoto and Sadakatsu Kyo and Shinya Kaneda and Miwa Harada and Sanae Kishimoto and Osamu Koshitani and Kazunobu Kurisu and Yoshifumi Nakashima},
  journal={The Journal of toxicological sciences},
  year={2003},
  volume={28 2},
  pages={95-107}
}
A 4-week intravenous repeated dose toxicity study of L-cysteine (L-Cys) was conducted in male Sprague-Dawley rats to investigate in detail the toxic effects of this compound and to determine the dose level at which these toxic effects are observed following repeated intravenous administration. Male rats were randomly allocated to 4 groups to receive L-Cys by intravenous administration at dosages of 0, 100, 300, and 1,000 mg/kg body weight/day. Body weight gain was significantly suppressed… CONTINUE READING