Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.

@article{Rutherford2008FourHT,
  title={Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.},
  author={Karen Rutherford and Valerie Daggett},
  journal={Journal of molecular biology},
  year={2008},
  volume={379 4},
  pages={803-14}
}
Thiopurine S-methyltransferase (TPMT) metabolizes cytotoxic thiopurine drugs used in the treatment of leukemia and inflammatory bowel disease. TPMT is a major pharmacogenomic target with 23 alleles identified to date. Several of these alleles cause rapid protein degradation and/or aggregation, making it extremely difficult to study the structural impact of the TPMT polymorphisms experimentally. We, therefore, have performed multiple molecular dynamics simulations of the four most common alleles… CONTINUE READING

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Structural Effects TPMT*2, *3A, *3B

  • L. Wang, T. V. Nguyen, R. W. McLaughlin, Sikkink
  • Proc. Natl Acad. Sci
  • 2005
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