Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility.


Human cells contain four homologous Ras proteins, but it is unknown whether each of these Ras proteins participates in distinct signal transduction cascades or has different biological functions. To directly address these issues, we assessed the relative ability of constitutively active (G12V) versions of each of the four Ras homologs to activate the… (More)