Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies.

@article{Wang2011FourGP,
  title={Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies.},
  author={Mingsong Wang and Xilong Lang and Liangjian Zou and Shengdong Huang and Zhiyun Xu},
  journal={Atherosclerosis},
  year={2011},
  volume={214 2},
  pages={377-85}
}
OBJECTIVE The human paraoxonase (PON) is calcium dependent HDL associated ester hydrolase which has attracted considerable attention as a candidate gene for coronary heart disease based on its enzyme function as a key factor in lipoprotein catabolism pathways. Many studies have examined the association between polymorphisms in the PON gene and risk of coronary heart disease (CHD), but the results have been inconsistent. METHODS We conducted a meta-analysis of 88 studies on 4 PON polymorphisms… CONTINUE READING

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