Four days of muscle disuse impairs single fiber contractile function in young and old healthy men.

@article{Hvid2013FourDO,
  title={Four days of muscle disuse impairs single fiber contractile function in young and old healthy men.},
  author={L G Hvid and Charlotte Suetta and Per Aagaard and Michael Kjaer and Ulrik Frandsen and Niels \Ortenblad},
  journal={Experimental gerontology},
  year={2013},
  volume={48 2},
  pages={154-61}
}
The purpose of the study was to investigate the effects of 4 days of disuse (knee brace) on contractile function of isolated vastus lateralis fibers (n=486) from 11 young (24.3±0.9 yrs) and 11 old (67.2±1.0 yrs) healthy men having comparable levels of physical activity. Prior to disuse single fiber specific force (maximal Ca(2+)-activated force per cross-sectional area) was lower in MHC I vs. IIa fibers (p<0.05) both in young (44%) and old (32%), and specific force of MHC IIa fibers was lower… CONTINUE READING
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