Four basic symmetry types in the universal 7-cluster structure of microbial genomic sequences

@article{Gorban2005FourBS,
  title={Four basic symmetry types in the universal 7-cluster structure of microbial genomic sequences},
  author={Alexander N. Gorban and Tatyana G. Popova and Andrei Yu. Zinovyev},
  journal={In silico biology},
  year={2005},
  volume={5 3},
  pages={265-82}
}
Coding information is the main source of heterogeneity (non-randomness) in the sequences of microbial genomes. The heterogeneity corresponds to a cluster structure in triplet distributions of relatively short genomic fragments (200-400 bp). We found a universal 7-cluster structure in microbial genomic sequences and explained its properties. We show that codon usage of bacterial genomes is a multi-linear function of their genomic G+C-content with high accuracy. Based on the analysis of 143… CONTINUE READING

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