Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza).

Abstract

Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.

DOI: 10.3390/molecules200814565

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@article{Yi2015FourNC, title={Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza).}, author={Xiang-xi Yi and Jia-gang Deng and Cheng-hai Gao and Xiao-Tao Hou and Fei Li and Zhiping Wang and Er-Wei Hao and Yan Xie and Zheng-Cai Du and Hui-xue Huang and Ri-Ming Huang}, journal={Molecules}, year={2015}, volume={20 8}, pages={14565-75} }