Four Irritating Odorants Target the Trigeminal Chemoreceptor TRPA1

@article{Richards2010FourIO,
  title={Four Irritating Odorants Target the Trigeminal Chemoreceptor TRPA1},
  author={Paige M. Richards and Erik C. Johnson and Wayne L. Silver},
  journal={Chemosensory Perception},
  year={2010},
  volume={3},
  pages={190-199}
}
The trigeminal nerve responds to a variety of nociceptive stimuli, including many chemicals that activate the olfactory system at lower concentrations. However, the mechanisms by which specific odorants activate the trigeminal nerve are largely undetermined. We used an integrative approach to determine whether TRPA1 channels were the target of eight olfactory stimuli known to activate the trigeminal nerve. In a mammalian cell line stably expressing the human TRPA1 channel, we observed… CONTINUE READING