Four IgG anti-islet human monoclonal antibodies isolated from a type 1 diabetes patient recognize distinct epitopes of glutamic acid decarboxylase 65 and are somatically mutated.

@article{Madec1996FourIA,
  title={Four IgG anti-islet human monoclonal antibodies isolated from a type 1 diabetes patient recognize distinct epitopes of glutamic acid decarboxylase 65 and are somatically mutated.},
  author={A. M. Madec and Françoise Rousset and Sarah Ho and Flavie Robert and Ch. Thivolet and Jacques Orgiazzi and Serge J. Lebecque},
  journal={Journal of immunology},
  year={1996},
  volume={156 9},
  pages={3541-9}
}
The selective destruction by an autoimmune process of the beta cells in the pancreas is the hallmark of the type 1 insulin-dependent diabetes mellitus. What triggers islet cell-specific autoreactive T and B cells, however, remains unclear. Identification of the targets of the anti-islet cell autoantibodies frequently found in insulin-dependent diabetes mellitus patients and analysis of their sequences should provide some insights into the nature of this disease. We have combined EBV… CONTINUE READING

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