Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

@inproceedings{Song2012FourES,
  title={Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321},
  author={Yongxiang Song and Jiajian Wang and Hongbo Huang and Lin Ma and Jun Wang and Yucheng Gu and Lan Liu and Yongcheng Lin},
  booktitle={Marine drugs},
  year={2012}
}
Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.