Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.

@article{Saxena2000FourDG,
  title={Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.},
  author={R Singh Saxena and Jan Willem de Vries and Sjoerd Repping and Raaji K. Alagappan and Helen Skaletsky and Laura G. Brown and Ping Ma and Eric Chen and Jan M. N. Hoovers and David C. Page},
  journal={Genomics},
  year={2000},
  volume={67 3},
  pages={256-67}
}
The DAZ genes are candidate fertility factors that lie within the human Y chromosome's AZFc region, whose deletion is a common cause of spermatogenic failure. The number of DAZ genes has been difficult to determine, in part because the nucleotide sequences of the DAZ genes are nearly identical. Here, fluorescence in situ hybridization and characterization of BAC clones revealed four full-length DAZ genes on the human Y chromosome. They exist in two clusters, each comprising an inverted pair of… CONTINUE READING
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