Founder mutations among the Dutch

@article{Zeegers2004FounderMA,
  title={Founder mutations among the Dutch},
  author={Maurice P. A. Zeegers and Frans W. A. van Poppel and Robert F M H Vlietinck and Liesbeth Spruijt and Harry Ostrer},
  journal={European Journal of Human Genetics},
  year={2004},
  volume={12},
  pages={591-600}
}
Many genetic disorders demonstrate mutations that can be traced to a founder, sometimes a person who can be identified. These founder mutations have generated considerable interest, because they facilitate studies of prevalence and penetrance and can be used to quantify the degree of homogeneity within a population. This paper reports on founder mutations among the Dutch and relates their occurrence to the history and demography of the Netherlands. International migration, regional and… CONTINUE READING

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