Founder effect in 20 Afrikaner kindreds with pseudoxanthoma elasticum.

  title={Founder effect in 20 Afrikaner kindreds with pseudoxanthoma elasticum.},
  author={Marie Torrington and Denis L. Viljoen},
  journal={South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
  volume={79 1},
The pedigrees of 20 families with pseudoxanthoma elasticum (PXE) were investigated. The analyses involved 13 generations up to and including the initial settlers, who arrived in the Cape before 1660. Four settler surnames predominate in these pedigrees. Because of the marriage patterns of the settlers' descendants it was necessary to classify the four surnames into two groups. It is suggested that these two groups are the founder groups of present-day PXE patients. Similar genealogical studies… CONTINUE READING