Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland.

@article{Looij2000FounderBM,
  title={Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland.},
  author={M van der Looij and Barbara A Wysocka and Izabela Brożek and Jacek Jassem and Janusz Limon and Edith Ol{\'a}h},
  journal={Human mutation},
  year={2000},
  volume={15 5},
  pages={480-1}
}
Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact of BRCA2 mutations in Poland, we have analyzed 25 high-risk breast and/or ovarian cancer families from North-Eastern Poland for mutations in all coding exons of the BRCA1 and BRCA2 genes, using… CONTINUE READING