Found in translation: functions and evolution of a recently discovered alternative proteome.

@article{Landry2015FoundIT,
  title={Found in translation: functions and evolution of a recently discovered alternative proteome.},
  author={Christian R. Landry and Xiangfu Zhong and Lou Nielly-Thibault and Xavier Roucou},
  journal={Current opinion in structural biology},
  year={2015},
  volume={32},
  pages={74-80}
}
A major goal in biology is to map entire proteomes to better understand the biology and evolution of cells. However, our current views of proteomes are conservative and biased against small proteins. Besides serendipitous discoveries of small proteins, it has been largely assumed that eukaryotic mature mRNAs contain a single ORF and that non-coding RNAs are not translated because their ORFs are too short to play a functional role. A flurry of recent studies brought to light an unexplored… CONTINUE READING
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